Correlation of Serum Concentrations with Heart Concentrations of Digoxin in Human Subjects
نویسندگان
چکیده
منابع مشابه
Correlation of serum concentrations with heart concentrations of digoxin in human subjects.
THE UTILITY OF THE ASSAY of serum levels of a drug implies a systematic relationship between this measurement and concentration of the drug at the site of action during "steady state" conditions. Data to support this relationship with respect to digoxin have been sparse, particularly with respect to man. One noteworthy finding is the observation both in animals' and in man2 that digoxin concent...
متن کاملClinical benefits of low serum digoxin concentrations in heart failure.
OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical ...
متن کاملSome observations on serum concentrations of digitoxin and digoxin.
Serum concentrations of digitoxin and digoxin were measured in 145 cases with various heart diseases receiving maintenance doses of digitalis. Digitalis toxicity was seen in only 2 cases (1.4%). Day-to-day variation of serum concentration while taking the same daily dose was small in digitoxin therapy (13.8%), but a considerable variation was seen in digoxin therapy (24.4%). Serum concentration...
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BACKGROUND Few data are available on the association of variables of the insulin resistance syndrome and serum ferritin, an indicator of body iron stores. We examined the relationship between serum ferritin levels and impaired fasting glucose, a pre-diabetes stage associated with insulin resistance, in this study. SUBJECTS & METHODS One hundred and eighty seven people, including 91 subjects w...
متن کاملRelationship Between Serum Digoxin Concentrations and Clinical Symptoms of Heart Failure in Pediatric Patients with Heart Disease
The objective of this study was to evaluate relationship between 3 SDC (serum digoxin concentration) subgroups (low, middle and high level) and clinical symptoms of HF (heart failure) in pediatric patients with heart disease. This study was carried out in 175 Thai pediatric patients who were treated with digoxin in routine care. SDCs on steady state were divided into 3 subgroups; low level: <0....
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ژورنال
عنوان ژورنال: Circulation
سال: 1974
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.50.4.653